Three people connected to the consulate were killed in drive-by shootings on Saturday in two separate incidents.
The US state department said the killings underscored the "severe and significant danger" Mexico represents to the United States.
Mexico has blamed the killings on a gang linked to a drugs cartel.
But investigators have said it is too early to tell if those killed were deliberately targeted.
"It could be a mistaken identity, it could be that they were targeted; we don't know at this point," special agent Andrea Simmons, a spokesman for the FBI's El Paso, Texas, office told Agence France-Presse.
Some eight FBI agents will be working alongside Mexican authorities in the investigation, she added.
Flashpoint city
On Saturday, Lesley Enrique - a US citizen working at the Juarez consulate - her American husband, Arthur Redelf, and Jorge Alberto Sarcido - the Mexican husband of another consular employee - were shot dead in two separate incidents.
Both couples had just left a social event in the city when they were killed.
Enriquez, 35, and her 34-year-old husband were killed in a hail of bullets as they drove their car towards the US side of the border. Their one-year-old baby was found unharmed in the back seat.
In the second attack, gunmen opened fire on the car belonging to Jorge Alberto Sarcido, killing him and wounding his two children.
The state department said the killings were a "tragedy".
"We all share the determination that, ultimately, through a variety of means, we will take back these streets one community at a time," state spokesman PJ Crowley told a news briefing.
His comments come a day ahead of a visit to the city by Mexican President Felipe Calderon, who will make his third tour this year of the country's most violent city to discuss the government's efforts to tackle organised crime.
Mexico is battling a drug war that has killed some 18,000 people since 2006.
Ciudad Juarez is a major flashpoint in the battle between Mexican drug gangs over trafficking routes to the US. More than 2,600 people were murdered there in drug-related violence last year alone.
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